Coltyp1-MM Flakes
Coltyp1- MM flakes
Treating chronic non-healing ulcers like diabetic foot ulcers, pressure sores etc is a real challenge for the surgeons.
Conventional treatment options available may not suffice or resolve the challenge of closing the wounds, in turn lead to various complex situations leading to devastating and catastrophic outcomes.
Such catastrophic and traumatic outcomes affect the quality of life badly, especially in case of diabetic foot ulcers patients leading to the extent of amputation.
This is for this reason medicated biomaterials like Coltyp1- MM flakes play a vital role in chronic wound management to alleviate the sufferings of millions of victims and their family members in this category
METRONIDAZOLE IP
Metronidazole topical cream is indicated in the treatment of Gram –ve bacterial infections (PDR 55th edn 2001 p 3075)
Topical formulation of metronidazole has proven effective in various skin disorders(Martindale -The extra Pharmacopoeia p 624)
Metronidazole has been used to treat anaerobic infections (Oxford text book of Medicine 3rd Edn Vol1 p 575)
Topical formulation of metronidazole has proven effective in various skin disorders(Martindale -The extra Pharmacopoeia p 624)
Metronidazole has been used to treat anaerobic infections (Oxford text book of Medicine 3rd Edn Vol1 p 575)
Role of collagen in Wound healing:
Collagen is a excellent Haemostatic agent (Hovig et al 1968)
Provides a matrix for tissue and vascular growth (klienman et al 1981a)
Binds with fibronectin which promotes cell binding(klienman et al 1981b)
Attracts fibroblasts and helps in directed migration of cells( Dunn & Ebendal 1978)
Helps in wound debridement by attracting monocytes
Binds with fibronectin which promotes cell binding(klienman et al 1981b)
Attracts fibroblasts and helps in directed migration of cells( Dunn & Ebendal 1978)
Helps in wound debridement by attracting monocytes
COLLAGEN:
Collagen is an extra cellular matrix protein playing a major role in connective tissue. It is the most abundant protein in humans and performs multiple functions. Collagen as a biomaterial and its role in wound management is well documented subject. Collagen encourages wound healing through the deposition and organization of freshly formed fibers and granulation tissues in the wound bed and thus creating a very conducive environment to wound healing
MUPIROCIN USP:
Topical Mupirocin is very effective against S.aureaus and this agent is invaluable in the eradication of Staphylococci (Oxford text book of Medicine 3rd Edn Vol1 p 526)
Mupirocin is an antibiotic used in the treatment of various bacterial skin disorders(Martindale -The extra Pharmacopoeia 31st edn p 251)
Mupirocin is an antibacterial agent and active against a wide range of gram +ve bacteria (PDR 55th edn 2001 p 3075)
Mupirocin is active against Strep. Pyogenes ( Penicillin sensitive /resistant), Staph. aureaus. MRSA, etc ( KD Tripathi- Essiential of medical pharmacology, 6th edn, p 733-34)
Mupirocin is an antibiotic used in the treatment of various bacterial skin disorders(Martindale -The extra Pharmacopoeia 31st edn p 251)
Mupirocin is an antibacterial agent and active against a wide range of gram +ve bacteria (PDR 55th edn 2001 p 3075)
Mupirocin is active against Strep. Pyogenes ( Penicillin sensitive /resistant), Staph. aureaus. MRSA, etc ( KD Tripathi- Essiential of medical pharmacology, 6th edn, p 733-34)
What is Coltyp1- MM flakes
Coltyp1- MM flakes is primarily a type 1 collagen in lyophilized flakes form with mupirocin USP 2%w/w and Metronidazole IP 1% w/w of specified volumes. Coltyp1- MM flakes is gamma sterilized and supplied in convenient easy to use pet containers. Coltyp1- MM flakes posses good absorbing characteristics and is non-toxic, non-allergic and no-immunogenic
Coltyp1- MM flakes are available in
Where Coltyp1- MM flakes can be used?
- Non healing ulcers
- Diabetic foot ulcers
- Pressure ulcers
- Venous ulcers
- Traumatic wounds
- Surgical wounds
- Infected wounds / burns
- Minimally to heavily draining wound
How to remove Coltyp1- MM flakes
Change as directed by the amount of drainage and instruction provided with the absorbent cover dressing
After removal of the cover dressing, repeat steps under product application as needed.
Precautions & Warnings:
Wound may appear to be larger during the initial days of treatment due to a reduction in swelling.
An increase in drainage may be seen on the initial days of treatment
The product is made from bovine source. DO NOT USE IF YOU ARE ALLERGIC TO BOVINE DERIVED MATERIALS, (Milk, Beef products , leather etc)
Discontinue use of Coltyp1- MM flakes if you experience redness, pain, swelling or blistering and inform your physician without delay.
Store at normal room temperature
After removal of the cover dressing, repeat steps under product application as needed.
Precautions & Warnings:
Wound may appear to be larger during the initial days of treatment due to a reduction in swelling.
An increase in drainage may be seen on the initial days of treatment
The product is made from bovine source. DO NOT USE IF YOU ARE ALLERGIC TO BOVINE DERIVED MATERIALS, (Milk, Beef products , leather etc)
Discontinue use of Coltyp1- MM flakes if you experience redness, pain, swelling or blistering and inform your physician without delay.
Store at normal room temperature
How to Apply Coltyp1- MM flakes
- Cleanse the wound
- Apply medication to the wound if indicated
- Apply Coltyp1- MM flakes ¼ inch thick to the wound surface. Do not pack tightly, allow for expansion of flakes.
- Cover with non stick dressing
- Use Coltyp1- MM flakes until wound is fully healed
- Maintain a moist wound environment